Annotation Overview for fig|224324.1.peg.468 in Aquifex aeolicus VF5:
DNA topoisomerase I (EC 5.99.1.2)

current assignment	DNA topoisomerase I (EC 5.99.1.2)	EC Number	5.99.1.2
taxonomy id	224324	contig	224324.1:NC_000918 (1,551,336bp)224324.1:NC_001880 (39,457bp)
internal links	genome browser | feature evidence | sequence	ACH Annotation Clearinghouse (ACH) The Annotation Clearinghouse offers a mapping of genes which are identical in sequence except for the start region (due to differences in start calling). [?]	show essentially identical genes
annotation history		run tool	Psi-BlastTMpredTMHMMGram negative PSORTGram negative SignalPGram positive PSORTGram positive SignalPLipoPInterProScanRadarPPSearchGram negative CELLOGram positive CELLOProDomPDB
FigFam	FIG000204
data base cross references (dbxref)	UniProt: TOP1_AQUAE NCBI: 2983253 NCBI: 6226245 UniProt: O66893 NCBI: 15606076 CMR: NTL01AA00464 RefSeq: NP_213453.1

Annotation History (history of similar genes)

Date	Annotator	Annotation
9/24/2004	MattC	Set FIG function to DNA topoisomerase I (EC 5.99.1.2)

We have assigned the function "DNA topoisomerase I (EC 5.99.1.2)" to the encoded protein. The protein occurs in 2 subsystems: "Conserved gene cluster associated with Met-tRNA formyltransferase", and "DNA topoisomerases, Type I, ATP-independent". In "Conserved gene cluster associated with Met-tRNA formyltransferase", it appears to play a functional role that we have not associated with any other gene. In "DNA topoisomerases, Type I, ATP-independent", it appears to play a functional role that we have not associated with any other gene. The function of genes having the same functional roles have been described in Schizosaccharomyces pombe (10572171), Drosophila melanogaster (10636841), Homo sapiens (8622991), Saccharomyces cerevisiae (15889139, 15899853, 2546682, 8336724), Thermotoga sp. (8547314), Haemophilus influenzae (8635745) and Mus musculus (9786843). These are homologous proteins which implement the same function.

The chromosomal region of the focus gene (top) is compared with four similar organisms. The graphic is centered on the focus gene, which is red and numbered 1. Sets of genes with similar sequence are grouped with the same number and color. Genes whose relative position is conserved in at least four other species are functionally coupled and share gray background boxes. The size of the region and the number of genomes may be reset. Click on any arrow in the display to refocus the comparison on that gene. The focus gene always points to the right, even if it is located on the minus strand.